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Given a candidate antibody sequence, the platform performs developability risk analysis across five dimensions — aggregation, chemical modification, humanness, polyreactivity, and viscosity — and outputs risk assessment results along with quantifiable metrics to support R&D teams in candidate comparison and selection.
Developability Analysis
Why Is This Needed?
"A candidate antibody's developability risk often only surfaces during scale-up or formulation studies — by then, going back to optimize the sequence carries far higher cost and time penalties. Assessing developability early across aggregation, chemical modification, humanness, polyreactivity, and viscosity helps identify potential risks during project selection and sequence design, providing guidance for subsequent experimental design."
Key Advantages
Traditional approaches often focus on a single dimension — such as aggregation or viscosity — and fail to fully capture an antibody's overall development risk.
Relies on experts manually comparing sequences against reference libraries and scanning modification sites one by one — slow and subject to individual judgment.
Focusing on a handful of known risk sites makes it difficult to systematically cover the full range of developability factors.
Aggregation, chemical modification, humanness, polyreactivity, and viscosity are all delivered at once with risk assessment results and quantitative metrics, comprehensively covering developability risk.
Uses analysis metrics such as SEC classification probability, PSR classification probability, DeepViscosity, and OASis to enable fast, batch evaluation of candidate sequences.
Uses multi-dimensional risk results to assist candidate comparison, helping teams quickly identify priority candidates.
Framework
Analyzes antibody candidates systematically based on multi-dimensional features such as sequence, structure, and physicochemical properties, covering five key dimensions: aggregation, chemical modification, humanness, polyreactivity, and viscosity.
| Dimension | Description | Analysis Metrics |
|---|---|---|
Aggregation | Assesses aggregation propensity and colloidal stability in solution, indicating potential risk for high-concentration formulation development. | SEC classification probability, PSH value, SAP developability index |
Chemical Modification | Identifies potential chemical liability sites, assessing chemical stability risk during long-term storage and manufacturing. | Potential chemical modification site analysis (e.g. Met oxidation, Asn deamidation, Trp oxidation, etc.) |
Humanness | Assesses the similarity of the antibody sequence to a human antibody reference library, reflecting its degree of humanness. | OASis percentile |
Polyreactivity | Assesses non-specific binding tendency toward non-target molecules, indicating potential polyreactivity risk. | PSR classification probability, PPC value |
Viscosity | Assesses viscosity behavior at high concentration, indicating potential risk for high-concentration formulation development. | DeepViscosity high-viscosity probability, SFvCSP value, Fv surface charge |
Assesses aggregation propensity and colloidal stability in solution, indicating potential risk for high-concentration formulation development.
SEC classification probability, PSH value, SAP developability index
Identifies potential chemical liability sites, assessing chemical stability risk during long-term storage and manufacturing.
Potential chemical modification site analysis (e.g. Met oxidation, Asn deamidation, Trp oxidation, etc.)
Assesses the similarity of the antibody sequence to a human antibody reference library, reflecting its degree of humanness.
OASis percentile
Assesses non-specific binding tendency toward non-target molecules, indicating potential polyreactivity risk.
PSR classification probability, PPC value
Assesses viscosity behavior at high concentration, indicating potential risk for high-concentration formulation development.
DeepViscosity high-viscosity probability, SFvCSP value, Fv surface charge
Pipeline
After submitting a candidate antibody sequence, the platform first performs structure prediction, then runs parallel scanning and risk grading across five dimensions, ultimately outputting multi-dimensional analysis results, metric details, and an AI-generated summary.
The system first generates a structure from the candidate sequence, then independently calculates quantifiable metrics for each dimension and outputs risk assessment results, ultimately generating a detailed metrics report based on the five-dimensional results.
Use Cases
Best suited for projects with candidate antibody sequences that need systematic developability risk assessment at an early stage.
Aggregation, chemical modification, humanness, polyreactivity, and viscosity. These five dimensions cover the major risk factors commonly considered during antibody development, and each dimension includes risk results together with quantifiable and traceable computational metrics.
Aggregation risk is assessed using metrics such as the SEC classification probability, PSH value, and SAP developability index to evaluate colloidal stability and potential aggregation propensity.
Chemical modification identifies potential chemical liability sites such as Met oxidation, Asn deamidation, and Trp oxidation, assessing stability risk during long-term storage and manufacturing. Viscosity uses the DeepViscosity high-viscosity probability, SFvCSP value, and Fv surface charge to assess viscosity risk at high concentration.
Humanness is evaluated using metrics such as the OASis percentile to measure how closely the sequence resembles a human antibody reference library, reflecting its degree of humanness. Polyreactivity is evaluated using metrics such as the PSR classification probability and PPC value to assess potential non-specific binding risk.
Five-dimensional developability assessment is now open for use. Submit a candidate antibody sequence to quickly get a risk radar report covering aggregation, chemical modification, humanness, polyreactivity, and viscosity.