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Real-World Antibody Discovery Challenge Program From Real Challenges to New Possibilities
2021–2026: Our First Five Years
Founded in June 2021, Clickmab was built with a clear mission: that antibody design should be driven by data and models, not trial and error.
Over the past five years, we have continuously advanced our AI-powered antibody discovery platform, developing capabilities across epitope-specific antibody design, CDR diversification, affinity maturation, and antibody humanization.
As we celebrate this milestone, we invite researchers and innovators to join us in exploring how AI can accelerate antibody discovery and unlock new scientific possibilities.
Program Structure
100 Free AI Design Opportunities
We will select 100 research projects and provide one AI-powered design service tailored to each project's specific needs.
- Epitope-Specific Antibody De Novo Design
- CDR Diversification
- Affinity Maturation
- Antibody Humanization
- Nanobody Humanization
3 Featured Collaborative Projects
Among the selected projects, three highly innovative and scientifically challenging programs will be chosen for deeper collaboration. Selected projects will receive:
- AI-driven design and computational support
- Expert interpretation of design results
- Dedicated technical support from the Clickmab R&D team
- Complimentary experimental validation support
Supported Directions
Participants can apply for free AI design tools in the following directions based on their needs:
Epitope-Specific De Novo Design
Design antibodies around a specified antigen epitope—ideal when the mechanism is clear but conventional immunization or screening struggles to deliver the target antibody.
CDR Diversity Engineering
Expand the explorable sequence space from an existing antibody, providing more candidates for downstream optimization.
Affinity Maturation
Identify key mutation sites and synergistic combinations to design more promising optimization strategies.
Antibody Humanization
Reduce potential immunogenicity risk while preserving the original binding properties and functional performance.
Nanobody Humanization
Dedicated humanization design and engineering optimization for VHH systems.
What Projects Are We Looking For?
We focus on real challenges with clear R&D value, such as:
- Antibody discovery against difficult epitopes around a specific mechanism of action
- A specific epitope or functional region is locked, seeking targeted design
- Candidate molecules in hand, seeking further optimization
- Concerned about activity or property loss during humanization
- Limited by experimental resources, hoping to expand sequence exploration
- Seeking new approaches for problems hard to solve with conventional methods
Whether at the early discovery stage or engineering optimization stage, all are welcome to apply.
How Do We Protect Your Data?
No sensitive information (targets, sequences, structures, experimental data) is required at registration. We only ask about:
- Your type of institution
- Your R&D focus areas
- Current technical challenges
- The type of support you need
All registration information is used only for review and follow-up, and will not be disclosed to third parties.
Timeline & Participation
Application Period
Project Review
Results Announcement
Platform Access Period
Why Are We Doing This?
Over the years, we have witnessed growing interest in applying AI to antibody discovery.
At the same time, we have observed a common challenge: many promising scientific questions remain difficult to address using traditional discovery approaches alone.
This program is our way of collaborating directly with researchers and innovators to explore new possibilities together.
Our Goal: To demonstrate how AI can create real value in antibody discovery and engineering through practical scientific collaboration.